Characterization of Breast Tumors from MR Images Using Radiomics and Machine Learning Approaches

نویسندگان

چکیده

Determining histological subtypes, such as invasive ductal and lobular carcinomas (IDCs ILCs) immunohistochemical markers, estrogen response (ER), progesterone (PR), the HER2 protein status is important in planning breast cancer treatment. MRI-based radiomic analysis emerging a non-invasive substitute for biopsy to determine these signatures. We explore effectiveness of radiomics-based CNN (convolutional neural network)-based classification models this end. T1-weighted dynamic contrast-enhanced, contrast-subtracted T1, T2-weighted MR images 429 tumors from 323 patients are used. Various combinations input data schemes applied ER+ vs. ER−, PR+ PR−, HER2+ HER2−, IDC ILC tasks. The best results were obtained ER− tasks, with their respective AUCs reaching 0.78 0.73 on test data. multi-contrast generally better than mono-contrast alone. radiomics CNN-based approaches exhibited comparable results. ER IDC/ILC promising. PR classifications need further investigation through larger dataset. Better by using might indicate that multi-parametric quantitative MRI could be used achieve more reliable classifiers.

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ژورنال

عنوان ژورنال: Journal of Personalized Medicine

سال: 2023

ISSN: ['2075-4426']

DOI: https://doi.org/10.3390/jpm13071062